"Do you speak English?"

There are different ways of asking questions, but why not keep it simple? For now, let's just add a question mark, and a rise in tone at the end of the sentence. It's not always the most common way to ask, but it will work:

Spanish ¿Usted habla inglés? = Italian Lei parla inglese? = French Vous parlez français? = "You speak English?"

Like the English, the phrasings may be a little stilted. But they'll get the job done.